There are thought to be nine-year and nine-month cycles of Ki/Qi on Earth, which are related to solar and seasonal cycles, and which have common effects across the planet on people’s mental and physical development and experiences throughout their lives. The 9 Star Ki ‘stars’ are numbers that represent those cycles.
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How is 9 Star Ki calculated?
Here is how you can calculate your own Nine Star Ki: Using your birth year, add up all the four digits. Continue to reduce the numbers by adding them until you have a single digit. If you were born after February 4th, you will subtract that number from 11.
What is a ki number?
A Ki (qi, chi, or kua) number is a basic concept in Feng Shui. A Ki (qi, chi, or kua) number is calculated based on one’s date of birth and gender (males are calculated differently than females).
What is considered a high Ki-67?
Understanding Your Ki-67 Results Less than 10% is considered low. 20% or higher is considered high.
What is Ki-67 positive?
The Ki-67 percentage score is defined as the percentage of positively stained tumor cells among the total number of malignant cells assessed [11]. Withal only the positivity is of interest independent of the intensity of coloration. To ensure quality assurance of the staining, positive control tissues are completed.
What does high Ki-67 mean?
Tumors are classified as having a high or low Ki-67 index based on a prespecified cutoff. Tumors with a high Ki-67 index have a larger number of proliferating cells and are therefore likely to grow more quickly.
Does a high Ki-67 mean chemo?
In subgroup analysis, a higher Ki-67 value (โฅ25%) was a significant predictive factor for the response to neoadjuvant chemotherapy, especially in ER-negative and HER2-positive breast cancer patients.
Does a high Ki-67 mean recurrence?
High-Ki 67 expression detected by IHC has been reported as the strongest individual prognostic factor of breast cancer death or recurrence in patients with T1 N0 M0 disease (Kronqvist et al, 2004).
What is Ki-67 80%?
The patients with high grade disease who achieved complete remission or good partial remission and had a Ki67 index of less than 80 per cent were more likely to relapse than those with an index of greater than 80 per cent (p less than 0.04).
How reliable is Ki-67?
No luminal A patients showed Ki-67 level higher than 15%, and their recurrence was 20%. In luminal B group, Ki-67 level higher than 15% was observed in 69% of patients, and recurrence was 39%. In HER2 subtype, Ki-67 was higher than 15% in 34% of cases, and recurrence was 40%.
How do you read a Ki-67?
The correct way of visual calculating Ki 67 is by counting the total number of positive-staining tumor cells in each image/field and count the total number of tumor cells in each image to calculate the Ki67 index. Calculation of the Ki67 index = No. of positive tumor cells/total No. of tumor cells ร100.
Is Ki-67 in normal cells?
Ki-67 is required for the normal cellular localization of heterochromatin-associated histone modifications (12) and for the interphase nucleolar association of heterochromatic loci (22).
Is it good to be HER2-positive or negative?
Breast cancer cells with higher than normal levels of HER2 are called HER2-positive. These cancers tend to grow and spread faster than breast cancers that are HER2-negative, but are much more likely to respond to treatment with drugs that target the HER2 protein.
What is Ki-67 in biopsy?
Biological tumor markers are used as measures of clinical efficacy when evaluating novel neo-adjuvant therapies., Ki67 is a biological tumor marker that follows changes in tumor proliferation between pre- and post-therapeutical samples, typically core biopsies and surgical samples [10,26,27].
What is the function of Ki-67?
During mitosis, Ki-67 is essential for formation of the perichromosomal layer (PCL), a ribonucleoprotein sheath coating the condensed chromosomes. In this structure, Ki-67 acts to prevent aggregation of mitotic chromosomes.
Is Ki-67 the same as Oncotype?
Background: Ki-67 is a marker of proliferating cells. The recurrence score based on the 21-gene breast cancer assay also called Oncotype Dx provides prognostic and predictive information for recurrence in early stage breast cancer patients.
How long does Ki67 last?
Ki67 was degraded continuously as long as cells remained quiescent, declining steadily for over 36 hr. Thus, Ki67 can serve as a marker for time since entry into quiescence, independent of the quiescence-inducing stimulus.
Can HER2-positive be cured?
HER2-positive breast cancer is highly curable because of the availability of these HER2-targeted therapies, so we treat patients fairly aggressively upfront to reduce the risk of them experiencing a stage IV recurrence.
Can HER2-negative Be Cured?
When you have HER2-negative advanced (metastatic) breast cancer, treatment usually focuses on managing your disease, not curing the cancer. The goal is to help you live longer and have a better quality of life. This type of cancer is most often treated with systemic therapy.
How long is chemo for HER2-positive?
Neoadjuvant therapy is typically administered for between 12 and 20 weeks, depending on the chosen regimen, and followed by surgery. When given as adjuvant chemotherapy following surgery, trastuzumab is given concurrently with chemotherapy, then continued for a total duration of 12 months.
Where is Ki67 found?
The gene encoding Ki67 is a continuous sequence of 29,965-bp length located on chromosome 10q25-ter and is comprised of 15 exons with sizes ranging from 67 to 6845 bp and 14 introns with sizes ranging from 87 to 3569 bp.
Has anyone had recurrence with low Oncotype?
There is a predicted recurrence rate of 6.8% at 10 years with an RS of less than 18, considered low, with the use of hormonal treatment alone.
What is the average Oncotype score?
The mean Oncotype Dx score was 17.0 ยฑ 9.1; it was 14.1 ยฑ 6.8 for Grade-I tumors; 15.7 ยฑ 7.5 for grade -II tumors; and 23.2 ยฑ 12.3 for grade-III tumors [Mean Oncotype Dx score across Tumor grades was compared by ANOVA (ฮท = 0.121), p < 0.001].
How reliable is the Oncotype test?
“Consistent with results from the NSABP and SWOG clinical validation studies of Oncotype DX, the new multiple prospective outcomes studies provide additional strong evidence of the test’s ability to accurately predict prospective outcomes regardless of age, tumour size and grade,” said Norman Wolmark, M.D., chairman of …
Why is it called Ki-67?
In 1983, a monoclonal antibody, Ki67, was generated, that labeled the nuclei of proliferating non-neoplastic and neoplastic cells. The name Ki67 derived from the city of Kiel (Ki) where the antibody was produced in the university department of pathology and refers to the number of the original clone (67).